Dr. Mustafa Unal, Prof. Bouxsein Group, Harvard

LISE 303 12pm-1pm May 9th 2025

Abstract: Bone strength is determined not only by bone mineral density but also by the molecular quality of its matrix—especially the organization of collagen, mineral, and water. Traditional clinical tools often overlook these critical compositional features. In this talk, I will present Raman spectroscopy as a powerful platform for capturing in situ biochemical signatures of bone. By quantifying key quality parameters such as the mineral-to-matrix ratio, collagen cross-linking, and matrix-bound water, this method reveals region-specific “quality fingerprints” that strongly correlate with fracture resistance of bone. Our studies in diabetic and osteoporotic bone underscore the potential of Raman spectroscopy to transform the way we assess bone fragility in both research and clinical contexts.

About the speaker: Mustafa Unal, PhD, is a Research Fellow at the Center for Advanced Orthopaedic Studies (CAOS) in the Department of Orthopaedic Surgery at Harvard Medical School and BIDMC. With training in mechanical and biomedical engineering, he integrates biomechanics and Raman spectroscopy to study bone quality and musculoskeletal disease. His innovative research has earned young investigator awards from the Society for Applied Spectroscopy, the Coblentz Society, FACSS, ORS, and ASBMR. His work spans diabetic bone fragility, spaceflight-induced bone loss, and the development of novel spectroscopic tools. Dr. Unal also serves as Editor-in-Chief of IFMRS HubLE and is a member of ASBMR’s Social Media Committee, where he promotes open science and early-career mentorship.